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Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme
How living systems detect the presence of genotoxic damage embedded in a million-fold excess of undamaged DNA is an unresolved question in biology. Here we have captured and structurally elucidated a base-excision DNA repair enzyme, MutM, at the stage of initial encounter with a damaged nucleobase,...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2951314/ https://ncbi.nlm.nih.gov/pubmed/20010681 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08561 |
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