A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA

A central mystery in the function of site-specific DNA-binding proteins is the detailed mechanism for rapid location and binding of target sites in DNA. Human oxoguanine DNA glycosylase 1 (hOgg1), for example, must search out rare 8-oxoguanine lesions to prevent transversion mutations arising from o...

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Bibliografiska uppgifter
Huvudupphovsmän: Blainey, Paul C., van Oijen, Antoine M., Banerjee, Anirban, Verdine, Gregory L., Xie, X. Sunney
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2006
Ämnen:
Physical Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1458645/
https://ncbi.nlm.nih.gov/pubmed/16585517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509723103
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