Mechanism of Hyperinsulinism in Short-chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency Involves Activation of Glutamate Dehydrogenase

The mechanism of insulin dysregulation in children with hyperinsulinism associated with inactivating mutations of short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) was examined in mice with a knock-out of the hadh gene (hadh(−/−)). The hadh(−/−) mice had reduced levels of plasma glucose and elevat...

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Auteurs principaux: Li, Changhong, Chen, Pan, Palladino, Andrew, Narayan, Srinivas, Russell, Laurie K., Sayed, Samir, Xiong, Guoxiang, Chen, Jie, Stokes, David, Butt, Yasmeen M., Jones, Patricia M., Collins, Heather W., Cohen, Noam A., Cohen, Akiva S., Nissim, Itzhak, Smith, Thomas J., Strauss, Arnold W., Matschinsky, Franz M., Bennett, Michael J., Stanley, Charles A.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2010
Sujets:
Metabolism
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951252/
https://ncbi.nlm.nih.gov/pubmed/20670938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.123638
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