Mechanism of Hyperinsulinism in Short-chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency Involves Activation of Glutamate Dehydrogenase

The mechanism of insulin dysregulation in children with hyperinsulinism associated with inactivating mutations of short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) was examined in mice with a knock-out of the hadh gene (hadh(−/−)). The hadh(−/−) mice had reduced levels of plasma glucose and elevat...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Li, Changhong, Chen, Pan, Palladino, Andrew, Narayan, Srinivas, Russell, Laurie K., Sayed, Samir, Xiong, Guoxiang, Chen, Jie, Stokes, David, Butt, Yasmeen M., Jones, Patricia M., Collins, Heather W., Cohen, Noam A., Cohen, Akiva S., Nissim, Itzhak, Smith, Thomas J., Strauss, Arnold W., Matschinsky, Franz M., Bennett, Michael J., Stanley, Charles A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Metabolism
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951252/
https://ncbi.nlm.nih.gov/pubmed/20670938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.123638
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares