Mechanism of Hyperinsulinism in Short-chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency Involves Activation of Glutamate Dehydrogenase

The mechanism of insulin dysregulation in children with hyperinsulinism associated with inactivating mutations of short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) was examined in mice with a knock-out of the hadh gene (hadh(−/−)). The hadh(−/−) mice had reduced levels of plasma glucose and elevat...

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Autors principals: Li, Changhong, Chen, Pan, Palladino, Andrew, Narayan, Srinivas, Russell, Laurie K., Sayed, Samir, Xiong, Guoxiang, Chen, Jie, Stokes, David, Butt, Yasmeen M., Jones, Patricia M., Collins, Heather W., Cohen, Noam A., Cohen, Akiva S., Nissim, Itzhak, Smith, Thomas J., Strauss, Arnold W., Matschinsky, Franz M., Bennett, Michael J., Stanley, Charles A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Metabolism
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951252/
https://ncbi.nlm.nih.gov/pubmed/20670938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.123638
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