Stabilization of Hypoxia-inducible Factor-1α Protein in Hypoxia Occurs Independently of Mitochondrial Reactive Oxygen Species Production

The transcription factor hypoxia-inducible factor-1α (HIF-1α) is a master regulator of the cellular response to low oxygen. HIF-1α protein accumulates in hypoxia due to inhibition of prolyl hydroxylase enzymes, which under normoxic conditions use molecular oxygen to hydroxylate HIF-1α on two conserv...

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Autori principali: Chua, Yee Liu, Dufour, Eric, Dassa, Emmanuel P., Rustin, Pierre, Jacobs, Howard T., Taylor, Cormac T., Hagen, Thilo
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951202/
https://ncbi.nlm.nih.gov/pubmed/20675386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.158485
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