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Compound C prevents Hypoxia-Inducible Factor-1α protein stabilization by regulating the cellular oxygen availability via interaction with Mitochondrial Complex I

The transcription factor Hypoxia-Inducible Factor-1α is a master regulator of the cellular response to low oxygen concentration. Compound C, an inhibitor of AMP-activated kinase, has been reported to inhibit hypoxia dependent Hypoxia-Inducible Factor-1α activation via a mechanism that is independent...

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Detalhes bibliográficos
Main Authors: Chua, Yee Liu, Hagen, Thilo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088540/
https://ncbi.nlm.nih.gov/pubmed/21481276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-0500-4-117
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