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Cutting Edge: T cell receptor ligation triggers digital activation of NF-κB

T cell receptor (TCR) mediated activation of the transcription factor NF-κB is required for T cell proliferation, survival, and effector differentiation. Although this pathway is the subject of intense study, it is not known whether TCR signaling to NF-κB is digital (switch-like) or analog in nature...

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Bibliografiske detaljer
Main Authors: Kingeter, Lara M., Paul, Suman, Maynard, Sean K., Cartwright, Natalia G., Schaefer, Brian C.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950878/
https://ncbi.nlm.nih.gov/pubmed/20855880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1001051
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