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The Viral Latency-Associated Nuclear Antigen Augments the B-Cell Response to Antigen In Vivo

Gammaherpesviruses, including Kaposi sarcoma-associated herpesvirus (KSHV), establish latency in B cells. We hypothesized that the KSHV latency-associated nuclear antigen (LANA/orf73) provides a selective advantage to infected B cells by driving proliferation in response to antigen. To test this, we...

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Detalhes bibliográficos
Main Authors: Sin, Sang-Hoon, Fakhari, Farnaz D., Dittmer, Dirk P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950586/
https://ncbi.nlm.nih.gov/pubmed/20686032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00848-10
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