Virulence Determinants of Avian H5N1 Influenza A Virus in Mammalian and Avian Hosts: Role of the C-Terminal ESEV Motif in the Viral NS1 Protein

We assessed the prediction that access of the viral NS1 protein to cellular PDZ domain protein networks enhances the virulence of highly pathogenic avian influenza A viruses. The NS1 proteins of most avian influenza viruses bear the C-terminal ligand sequence Glu-Ser-Glu-Val (ESEV) for PDZ domains p...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Zielecki, Florian, Semmler, Ilia, Kalthoff, Donata, Voss, Daniel, Mauel, Susanne, Gruber, Achim D., Beer, Martin, Wolff, Thorsten
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology (ASM) 2010
Ämnen:
Virus-Cell Interactions
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950580/
https://ncbi.nlm.nih.gov/pubmed/20686040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00610-10
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk