Virulence Determinants of Avian H5N1 Influenza A Virus in Mammalian and Avian Hosts: Role of the C-Terminal ESEV Motif in the Viral NS1 Protein

We assessed the prediction that access of the viral NS1 protein to cellular PDZ domain protein networks enhances the virulence of highly pathogenic avian influenza A viruses. The NS1 proteins of most avian influenza viruses bear the C-terminal ligand sequence Glu-Ser-Glu-Val (ESEV) for PDZ domains p...

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Autores principales: Zielecki, Florian, Semmler, Ilia, Kalthoff, Donata, Voss, Daniel, Mauel, Susanne, Gruber, Achim D., Beer, Martin, Wolff, Thorsten
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2010
Materias:
Virus-Cell Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950580/
https://ncbi.nlm.nih.gov/pubmed/20686040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00610-10
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