The Type I Interferon Signaling Pathway Is a Target for Glucocorticoid Inhibition

Type I interferon (IFN) is essential for host defenses against viruses; however, dysregulated IFN signaling is causally linked to autoimmunity, particularly systemic lupus erythematosus. Autoimmune disease treatments rely on glucocorticoids (GCs), which act via the GC receptor (GR) to repress proinf...

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Autori principali: Flammer, Jamie R., Dobrovolna, Jana, Kennedy, Megan A., Chinenov, Yurii, Glass, Christopher K., Ivashkiv, Lionel B., Rogatsky, Inez
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2010
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950533/
https://ncbi.nlm.nih.gov/pubmed/20679482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00146-10
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