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The Type I Interferon Signaling Pathway Is a Target for Glucocorticoid Inhibition
Type I interferon (IFN) is essential for host defenses against viruses; however, dysregulated IFN signaling is causally linked to autoimmunity, particularly systemic lupus erythematosus. Autoimmune disease treatments rely on glucocorticoids (GCs), which act via the GC receptor (GR) to repress proinf...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2950533/ https://ncbi.nlm.nih.gov/pubmed/20679482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00146-10 |
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