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The Type I Interferon Signaling Pathway Is a Target for Glucocorticoid Inhibition

Type I interferon (IFN) is essential for host defenses against viruses; however, dysregulated IFN signaling is causally linked to autoimmunity, particularly systemic lupus erythematosus. Autoimmune disease treatments rely on glucocorticoids (GCs), which act via the GC receptor (GR) to repress proinf...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Flammer, Jamie R., Dobrovolna, Jana, Kennedy, Megan A., Chinenov, Yurii, Glass, Christopher K., Ivashkiv, Lionel B., Rogatsky, Inez
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950533/
https://ncbi.nlm.nih.gov/pubmed/20679482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00146-10
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