A Francisella tularensis Live Vaccine Strain (LVS) Mutant with a Deletion in capB, Encoding a Putative Capsular Biosynthesis Protein, Is Significantly More Attenuated than LVS yet Induces Potent Protective Immunity in Mice against F. tularensis Challenge

Francisella tularensis, the causative agent of tularemia, is in the top category (category A) of potential agents of bioterrorism. The F. tularensis live vaccine strain (LVS) is the only vaccine currently available to protect against tularemia; however, this unlicensed vaccine is relatively toxic an...

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Detalhes bibliográficos
Main Authors: Jia, Qingmei, Lee, Bai-Yu, Bowen, Richard, Dillon, Barbara Jane, Som, Susan M., Horwitz, Marcus A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950357/
https://ncbi.nlm.nih.gov/pubmed/20643859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00192-10
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