A Heterologous Prime-Boost Vaccination Strategy Comprising the Francisella tularensis Live Vaccine Strain capB Mutant and Recombinant Attenuated Listeria monocytogenes Expressing F. tularensis IglC Induces Potent Protective Immunity in Mice against Virulent F. tularensis Aerosol Challenge

Francisella tularensis, the causative agent of tularemia, is a category A bioterrorism agent. A vaccine that is safer and more effective than the currently available unlicensed F. tularensis live vaccine strain (LVS) is needed to protect against intentional release of aerosolized F. tularensis, the...

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Detalhes bibliográficos
Principais autores: Jia, Qingmei, Bowen, Richard, Sahakian, Jacob, Dillon, Barbara Jane, Horwitz, Marcus A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3647989/
https://ncbi.nlm.nih.gov/pubmed/23439306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01013-12
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