Protein Phosphatase 2A Negatively Regulates Eukaryotic Initiation Factor 4E Phosphorylation and eIF4F Assembly through Direct Dephosphorylation of Mnk and eIF4E

The eukaryotic translation initiation factor 4E (eIF4E) is frequently overexpressed in human cancers and is associated with cellular transformation, tumorigenesis, and metastatic progression. It is known that Mnks can phosphorylate eIF4E. Protein phosphatase 2A (PP2A) functions as a tumor suppressor...

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Bibliographic Details
Main Authors: Li, Yikun, Yue, Ping, Deng, Xingming, Ueda, Takeshi, Fukunaga, Rikiro, Khuri, Fadlo R, Sun, Shi-Yong
Format: Artigo
Language:Inglês
Published: Neoplasia Press Inc. 2010
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950334/
https://ncbi.nlm.nih.gov/pubmed/20927323
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