Protein Phosphatase 2A Negatively Regulates Eukaryotic Initiation Factor 4E Phosphorylation and eIF4F Assembly through Direct Dephosphorylation of Mnk and eIF4E

The eukaryotic translation initiation factor 4E (eIF4E) is frequently overexpressed in human cancers and is associated with cellular transformation, tumorigenesis, and metastatic progression. It is known that Mnks can phosphorylate eIF4E. Protein phosphatase 2A (PP2A) functions as a tumor suppressor...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Li, Yikun, Yue, Ping, Deng, Xingming, Ueda, Takeshi, Fukunaga, Rikiro, Khuri, Fadlo R, Sun, Shi-Yong
Formato: Artigo
Lenguaje:Inglês
Publicado: Neoplasia Press Inc. 2010
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950334/
https://ncbi.nlm.nih.gov/pubmed/20927323
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares