MEK/ERK-Mediated Phosphorylation of Bim is Required to Ensure Survival of T and B Lymphocytes during Mitogenic Stimulation

Survival and death of lymphocytes is regulated by the balance between pro- and anti-apoptotic members of the Bcl-2 family, and this is coordinated with the control of cell cycling and differentiation. Bim, a pro-apoptotic BH3-only member of the Bcl-2 family, can be regulated by MEK/ERK-mediated phos...

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Detaylı Bibliyografya
Asıl Yazarlar: O’Reilly, Lorraine A, Kruse, Elizabeth A, Puthalakath, Hamsa, Kelly, Priscilla N, Kaufmann, Thomas, Huang, David CS, Strasser, Andreas
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2009
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950174/
https://ncbi.nlm.nih.gov/pubmed/19542438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0803853
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