Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations

We investigated a series of coumarinyl-substituted aromatic sulfonamides as inhibitors of four carbonic anhydrase (CA, EC 4.2.1.1) isoforms with medical applications, the cytosolic hCA I, and II, and the transmembrane, tumor-associated hCA IX and XII. Compounds incorporating 7-methoxy-coumarin-4-yl-...

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Bibliografiske detaljer
Main Authors: Wagner, Jason, Avvaru, Balendu Sankara, Robbins, Arthur H., Scozzafava, Andrea, Supuran, Claudiu T., McKenna, Robert
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950089/
https://ncbi.nlm.nih.gov/pubmed/20598552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.06.028
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