Synthetic heterochromatin bypasses RNAi and centromeric repeats to establish functional centromeres

In the central domain of fission yeast centromeres the kinetochore is assembled upon CENP-A(Cnp1) nucleosomes. Normally, siRNAs generated from flanking outer repeat transcripts direct histone H3 lysine 9 methyltransferase Clr4 to homologous loci to form heterochromatin. Outer repeats, RNAi and centr...

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Hlavní autoři: Kagansky, Alexander, Folco, Hernan Diego, Almeida, Ricardo, Pidoux, Alison L., Boukaba, Abdelhalim, Simmer, Femke, Urano, Takeshi, Hamilton, Georgina L., Allshire, Robin C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949999/
https://ncbi.nlm.nih.gov/pubmed/19556509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1172026
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