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Distinct roles for Sir2 and RNAi in centromeric heterochromatin nucleation, spreading and maintenance
Epigenetically regulated heterochromatin domains govern essential cellular activities. A key feature of heterochromatin domains is the presence of hypoacetylated nucleosomes, which are methylated on lysine 9 of histone H3 (H3K9me). Here, we investigate the requirements for establishment, spreading a...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
European Molecular Biology Organization
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3642681/ https://ncbi.nlm.nih.gov/pubmed/23572080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.72 |
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