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Synthetic heterochromatin bypasses RNAi and centromeric repeats to establish functional centromeres
In the central domain of fission yeast centromeres the kinetochore is assembled upon CENP-A(Cnp1) nucleosomes. Normally, siRNAs generated from flanking outer repeat transcripts direct histone H3 lysine 9 methyltransferase Clr4 to homologous loci to form heterochromatin. Outer repeats, RNAi and centr...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2949999/ https://ncbi.nlm.nih.gov/pubmed/19556509 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1172026 |
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