Gamma-glutamyl carboxylase and its influence on warfarin dose

BACKGROUND: Via generation of vitamin K-dependent proteins, gamma-glutamyl carboxylase (GGCX) plays a critical role in the vitamin K cycle. Single nucleotide polymorphisms (SNPs) in GGCX, therefore, may affect dosing of the vitamin K antagonist, warfarin. METHODS: In a multi-centered, cross-sectiona...

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Main Authors: King, Cristi R., Deych, Elena, Milligan, Paul, Eby, Charles, Lenzini, Petra, Grice, Gloria, Porche-Sorbet, Rhonda M., Ridker, Paul M., Gage, Brian F.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949522/
https://ncbi.nlm.nih.gov/pubmed/20694283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1160/TH09-11-0763
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