Genetic-based dosing in orthopedic patients beginning warfarin therapy

High variability in drug response and a narrow therapeutic index complicate warfarin therapy initiation. No existing algorithm provides recommendations on refining the initial warfarin dose based on genetic variables, clinical data, and international normalized ratio (INR) values. Our goal was to de...

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Bibliografske podrobnosti
Main Authors: Millican, Eric A., Lenzini, Petra A., Milligan, Paul E., Grosso, Leonard, Eby, Charles, Deych, Elena, Grice, Gloria, Clohisy, John C., Barrack, Robert L., Burnett, R. Stephen J., Voora, Deepak, Gatchel, Susan, Tiemeier, Amy, Gage, Brian F.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2007
Teme:
Hemostasis, Thrombosis, and Vascular Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1975838/
https://ncbi.nlm.nih.gov/pubmed/17387222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-01-069609
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