Genetic-based dosing in orthopedic patients beginning warfarin therapy

High variability in drug response and a narrow therapeutic index complicate warfarin therapy initiation. No existing algorithm provides recommendations on refining the initial warfarin dose based on genetic variables, clinical data, and international normalized ratio (INR) values. Our goal was to de...

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Hauptverfasser: Millican, Eric A., Lenzini, Petra A., Milligan, Paul E., Grosso, Leonard, Eby, Charles, Deych, Elena, Grice, Gloria, Clohisy, John C., Barrack, Robert L., Burnett, R. Stephen J., Voora, Deepak, Gatchel, Susan, Tiemeier, Amy, Gage, Brian F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2007
Schlagworte:
Hemostasis, Thrombosis, and Vascular Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1975838/
https://ncbi.nlm.nih.gov/pubmed/17387222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-01-069609
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