A polymorphism in the VKORC1-regulator calumenin predicts higher warfarin doses in African-Americans

BACKGROUND: Warfarin demonstrates wide interindividual variability that is partly mediated by variants in CYP2C9 and VKORC1. Whether variants in CALU (vitamin K reductase regulator) influence warfarin dose is unknown. METHODS AND RESULTS: We resequenced CALU regions in a discovery cohort of dose-out...

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Main Authors: Voora, D, Koboldt, DC, King, CR, Lenzini, PA, Eby, CS, Porche-Sorbet, R, Deych, E, Crankshaw, M, Milligan, PE, McLeod, HL, Patel, SR, Cavallari, LH, Ridker, PM, Grice, GR, Miller, RD, Gage, BF
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928561/
https://ncbi.nlm.nih.gov/pubmed/20200517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2009.291
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