The Potent Synthetic Androgens, Dimethandrolone (7α,11β-Dimethyl-19-Nortestosterone) and 11β-Methyl-19-Nortestosterone, Do Not Require 5α-Reduction to Exert their Maximal Androgenic Effects

Dimethandrolone (DMA: 7α,11β-dimethyl-19-nortestosterone) and 11β-methyl-19-nortestosterone (MNT) are potent androgens in development for hormonal therapy in men. As 5α-reduced androgens, such as 5α-dihydrotestosterone (DHT), may raise the risk of benign prostate hyperplasia, accelerate the developm...

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Main Authors: Attardi, Barbara J., Hild, Sheri A., Koduri, Sailaja, Pham, Trung, Pessaint, Laurent, Engbring, Jean, Till, Bruce, Gropp, David, Semon, Anne, Reel, Jerry R.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949447/
https://ncbi.nlm.nih.gov/pubmed/20599615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2010.06.009
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