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Dimethandrolone (7α,11β-dimethyl-19-nortestosterone) and 11β-methyl-19-nortestosterone are not converted to aromatic A-ring products in the presence of recombinant human aromatase

Dimethandrolone undecanoate (DMAU: 7α,11β-dimethyl-19-nortestosterone 17β-undecanoate) is a potent orally active androgen in development for hormonal therapy in men. Cleavage of the 17β-ester bond by esterases in vivo leads to liberation of the biologically active androgen, dimethandrolone (DMA), a...

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Detalhes bibliográficos
Main Authors: Attardi, Barbara J., Pham, Trung C., Radler, Lisa M., Burgenson, Janet, Hild, Sheri A., Reel, Jerry R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575079/
https://ncbi.nlm.nih.gov/pubmed/18555683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2007.11.009
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