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CD4(+) CD25(+) Foxp3(+) T regulatory cells with limited T cell receptor diversity in control of autoimmunity
The importance of high TCR diversity of Treg cells for self-tolerance is poorly understood. To address this issue, TCR diversity was measured for Treg cells after transfer into IL-2Rβ(-/-) mice, which develop lethal autoimmunity due to failed production of Treg cells. Here we show that high TCR dive...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2949410/ https://ncbi.nlm.nih.gov/pubmed/19949075 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902379 |
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