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CD4(+) CD25(+) Foxp3(+) T regulatory cells with limited T cell receptor diversity in control of autoimmunity

The importance of high TCR diversity of Treg cells for self-tolerance is poorly understood. To address this issue, TCR diversity was measured for Treg cells after transfer into IL-2Rβ(-/-) mice, which develop lethal autoimmunity due to failed production of Treg cells. Here we show that high TCR dive...

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Autori principali: Adeegbe, Dennis, Matsutani, Takaji, Yang, Jing, Altman, Norman H., Malek, Thomas R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949410/
https://ncbi.nlm.nih.gov/pubmed/19949075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902379
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