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The lower limit of regulatory CD4(+) Foxp3(+) TCRβ repertoire diversity required to control autoimmunity
The TCR repertoire of regulatory T cells (Tregs) is highly diverse. The relevance of this diversity to maintain self-tolerance remains unknown. We established a model where the TCR repertoire of normal polyclonal Tregs was limited by serial transfers into IL-2Rβ(−/−) mice, which lack functional Treg...
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| Published in: | J Immunol |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5381961/ https://ncbi.nlm.nih.gov/pubmed/28264971 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1601966 |
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