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Accommodation of physostigmine and its analogs by acetylcholinesterase is dominated by hydrophobic interactions
The role of the functional architecture of the human acetylcholinesterase (HuAChE) in reactivity toward the carbamates pyridostigmine, rivastigmine and several analogs of physostigmine, that are currently used or considered for use as drugs for Alzheimer’s disease, was analysed using over 20 mutants...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2949283/ https://ncbi.nlm.nih.gov/pubmed/18729824 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20081276 |
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