Aging of phosphylated human acetylcholinesterase: catalytic processes mediated by aromatic and polar residues of the active centre.

We have examined the effects of 11 substitutions of active centre gorge residues of human acetylcholinesterase (HuAChE) on the rates of phosphonylation by 1,2,2-trimethylpropyl methyl-phosphonofluoridate (soman) and the aging of the resulting conjugates. The rates of phosphonylation were reduced to...

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Autores principales: Shafferman, A, Ordentlich, A, Barak, D, Stein, D, Ariel, N, Velan, B
Formato: Artigo
Lenguaje:Inglês
Publicado: 1996
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1217693/
https://ncbi.nlm.nih.gov/pubmed/8836126
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