Substrate inhibition of acetylcholinesterase: residues affecting signal transduction from the surface to the catalytic center.

Amino acids located within and around the 'active site gorge' of human acetylcholinesterase (AChE) were substituted. Replacement of W86 yielded inactive enzyme molecules, consistent with its proposed involvement in binding of the choline moiety in the active center. A decrease in affinity...

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Detalhes bibliográficos
Main Authors: Shafferman, A, Velan, B, Ordentlich, A, Kronman, C, Grosfeld, H, Leitner, M, Flashner, Y, Cohen, S, Barak, D, Ariel, N
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC556814/
https://ncbi.nlm.nih.gov/pubmed/1396557
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