Small elevations of glucose concentration redirect and amplify the synthesis of guanosine 5'-triphosphate in rat islets.

Recent studies suggest a permissive requirement for guanosine 5'-triphosphate (GTP) in insulin release, based on the use of GTP synthesis inhibitors (such as myocophenolic acid) acting at inosine monophosphate (IMP) dehydrogenase; herein, we examine the glucose dependency of GTP synthesis. Mycopheno...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Metz, S A, Meredith, M, Rabaglia, M E, Kowluru, A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294926/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8349822/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116662
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