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Small elevations of glucose concentration redirect and amplify the synthesis of guanosine 5'-triphosphate in rat islets.

Recent studies suggest a permissive requirement for guanosine 5'-triphosphate (GTP) in insulin release, based on the use of GTP synthesis inhibitors (such as myocophenolic acid) acting at inosine monophosphate (IMP) dehydrogenase; herein, we examine the glucose dependency of GTP synthesis. Mycopheno...

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書目詳細資料
發表在:J Clin Invest
Principais autores: Metz, S A, Meredith, M, Rabaglia, M E, Kowluru, A
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 1993
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在線閱讀:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294926/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8349822/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116662
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