Elevated Levels of DNA Strand Breaks Induced by a Base Analog in the Human Cell Line with the P32T ITPA Variant

Base analogs are powerful antimetabolites and dangerous mutagens generated endogenously by oxidative stress, inflammation, and aberrant nucleotide biosynthesis. Human inosine triphosphate pyrophosphatase (ITPA) hydrolyzes triphosphates of noncanonical purine bases (i.e., ITP, dITP, XTP, dXTP, or the...

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Detalhes bibliográficos
Main Authors: Waisertreiger, Irina S.-R., Menezes, Miriam R., Randazzo, James, Pavlov, Youri I.
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE-Hindawi Access to Research 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2948936/
https://ncbi.nlm.nih.gov/pubmed/20936128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2010/872180
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