Functional Study of the P32T ITPA Variant Associated with Drug Sensitivity in Humans

Sanitization of the cellular nucleotide pools from mutagenic base analogs is necessary for the accuracy of transcription and replication of genetic material and plays a substantial role in cancer prevention. The undesirable mutagenic, recombinogenic and toxic incorporation of purine base analogs (i....

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Main Authors: Stepchenkova, Elena I., Tarakhovskaya, Elena R., Spitler, Kathryn, Frahm, Christin, Menezes, Miriam R., Simone, Peter D., Kolar, Carol, Marky, Luis A., Borgstahl, Gloria E. O., Pavlov, Youri I.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745931/
https://ncbi.nlm.nih.gov/pubmed/19631656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.07.051
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