An inbred line of transgenic mice expressing an internally deleted gene for type II procollagen (COL2A1). Young mice have a variable phenotype of a chondrodysplasia and older mice have osteoarthritic changes in joints.

Studies were carried out on a line of transgenic mice that expressed an internally deleted COL2A1 gene and developed a phenotype resembling human chondrodysplasias (Vandenberg et al. 1991. Proc. Natl. Acad. Sci. USA. 88:7640-7644. Marked differences in phenotype were observed with propagation of the...

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Detalhes bibliográficos
Main Authors: Helminen, H J, Kiraly, K, Pelttari, A, Tammi, M I, Vandenberg, P, Pereira, R, Dhulipala, R, Khillan, J S, Ala-Kokko, L, Hume, E L
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC294889/
https://ncbi.nlm.nih.gov/pubmed/8349798
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