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Expression of a partially deleted gene of human type II procollagen (COL2A1) in transgenic mice produces a chondrodysplasia.

A minigene version of the human gene for type II procollagen (COL2A1) was prepared that lacked a large central region containing 12 of the 52 exons and therefore 291 of the 1523 codons of the gene. The construct was modeled after sporadic in-frame deletions of collagen genes that cause synthesis of...

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Bibliografske podrobnosti
Main Authors: Vandenberg, P, Khillan, J S, Prockop, D J, Helminen, H, Kontusaari, S, Ala-Kokko, L
Format: Artigo
Jezik:Inglês
Izdano: 1991
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC52357/
https://ncbi.nlm.nih.gov/pubmed/1881905
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