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Over-expression and hypomethylation of flap endonuclease 1 gene in breast and other cancers

Flap endonuclease1 (FEN1) is a structure-specific nuclease best known for its critical roles in Okazaki fragment maturation, DNA repair and apoptosis-induced DNA fragmentation. Functional deficiencies in FEN1, in the forms of somatic mutations and polymorphisms, have recently been shown to lead to a...

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Detalhes bibliográficos
Main Authors: Singh, Purnima, Yang, Ming, Dai, Huifang, Yu, Dianke, Huang, Qin, Tan, Wen, Kernstine, Kemp, Lin, Dongxin, Shen, Binghui
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2948671/
https://ncbi.nlm.nih.gov/pubmed/19010819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-08-0269
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