Prognostic Impact of Bim, Puma, and Noxa Expression in Human Colon Carcinomas

PURPOSE: Proapoptotic BH3-only proteins (Bim, Bad, Bid, Puma, and Noxa) initiate apoptosis by binding to regulatory sites on antiapoptotic Bcl-2 proteins, directly neutralizing their cytoprotective function. Expression of these proteins in colon cancer patients may account for differences in recurre...

Full description

Saved in:
Bibliographic Details
Main Authors: Sinicrope, Frank A., Rego, Rafaela L., Okumura, Kenji, Foster, Nathan R., O’Connell, Michael J., Sargent, Daniel J., Windschitl, Harold E.
Format: Artigo
Language:Inglês
Published: 2008
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2948480/
https://ncbi.nlm.nih.gov/pubmed/18794091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-07-5202
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items