Prognostic Impact of Bim, Puma, and Noxa Expression in Human Colon Carcinomas

PURPOSE: Proapoptotic BH3-only proteins (Bim, Bad, Bid, Puma, and Noxa) initiate apoptosis by binding to regulatory sites on antiapoptotic Bcl-2 proteins, directly neutralizing their cytoprotective function. Expression of these proteins in colon cancer patients may account for differences in recurre...

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Detaylı Bibliyografya
Asıl Yazarlar: Sinicrope, Frank A., Rego, Rafaela L., Okumura, Kenji, Foster, Nathan R., O’Connell, Michael J., Sargent, Daniel J., Windschitl, Harold E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2008
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2948480/
https://ncbi.nlm.nih.gov/pubmed/18794091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-07-5202
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