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Structural, NMR Spectroscopic and Computational Investigation of Hemin Loading in the Hemophore HasAp from Pseudomonas aeruginosa

When challenged by low-iron conditions several Gram-negative pathogens secrete a hemophore (HasA) to scavenge hemin from its host and deliver it to a receptor (HasR) on their outer membrane for internalization. Here we report results from studies aimed at probing the structural and dynamic processes...

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Detalhes bibliográficos
Main Authors: Jepkorir, Grace, Rodríguez, Juan Carlos, Rui, Huan, Im, Wonpil, Lovell, Scott, Battaile, Kevin P., Alontaga, Aileen Y., Yukl, Erik T., Moënne-Loccoz, Pierre, Rivera, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2948407/
https://ncbi.nlm.nih.gov/pubmed/20572666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja103498z
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