Replacing Arginine 33 for Alanine in the Hemophore HasA from Pseudomonas aeruginosa Causes Closure of the H32 Loop in the Apo-Protein

Previous characterization of hemophores from Serratia marcescens (HasAs), Pseudomonas aeruginosa (HasAp) and Yersinia pestis (HasA(yp)) showed that hemin binds between two loops, where it is axially coordinated by H32 and Y75. The Y75 loop is structurally conserved in all three hemophores and harbor...

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Veröffentlicht in:Biochemistry
Hauptverfasser: Kumar, Ritesh, Qi, Yifei, Matsumura, Hirotoshi, Lovell, Scott, Yao, Huili, Battaile, Kevin P., Im, Wonpil, Moënne-Loccoz, Pierre, Rivera, Mario
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550100/
https://ncbi.nlm.nih.gov/pubmed/27074415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00239
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