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Functional analysis of Lyn kinase A and B isoforms reveals redundant and distinct roles in FcεRI-dependent mast cell activation
Engagement of the high affinity receptor for IgE (FcεRI) causes its phosphorylation by Lyn kinase. Two alternatively spliced variants, Lyn A and B are expressed in mast cells and both isoforms interact with FcεRI. Unlike Lyn A, Lyn B lacks a 21 amino acid region in the NH(2)-terminal unique domain....
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2948211/ https://ncbi.nlm.nih.gov/pubmed/20308635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0904064 |
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