IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis

BACKGROUND: Myelodysplastic syndromes are a heterogeneous group of hematopoietic stem cell disorders with a high propensity to transform into acute myeloid leukemia. Heterozygous missense mutations in IDH1 at position R132 and in IDH2 at positions R140 and R172 have recently been reported in acute m...

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Detalhes bibliográficos
Main Authors: Thol, Felicitas, Weissinger, Eva M., Krauter, Jürgen, Wagner, Katharina, Damm, Frederik, Wichmann, Martin, Göhring, Gudrun, Schumann, Christiane, Bug, Gesine, Ottmann, Oliver, Hofmann, Wolf-Karsten, Schlegelberger, Brigitte, Ganser, Arnold, Heuser, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2948091/
https://ncbi.nlm.nih.gov/pubmed/20494930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2010.025494
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