PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas

Gene rearrangement in the form of an intragenic deletion is the primary mechanism of oncogenic mutation of the epidermal growth factor receptor (EGFR) gene in gliomas. However, the incidence of platelet-derived growth factor receptor-α (PDGFRA) gene rearrangement in these tumors is unknown. We inves...

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Main Authors: Ozawa, Tatsuya, Brennan, Cameron W., Wang, Lu, Squatrito, Massimo, Sasayama, Takashi, Nakada, Mitsutoshi, Huse, Jason T., Pedraza, Alicia, Utsuki, Satoshi, Yasui, Yoshie, Tandon, Adesh, Fomchenko, Elena I., Oka, Hidehiro, Levine, Ross L., Fujii, Kiyotaka, Ladanyi, Marc, Holland, Eric C.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2010
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947772/
https://ncbi.nlm.nih.gov/pubmed/20889717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1972310
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