PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas

Gene rearrangement in the form of an intragenic deletion is the primary mechanism of oncogenic mutation of the epidermal growth factor receptor (EGFR) gene in gliomas. However, the incidence of platelet-derived growth factor receptor-α (PDGFRA) gene rearrangement in these tumors is unknown. We inves...

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Bibliografiska uppgifter
Huvudupphovsmän: Ozawa, Tatsuya, Brennan, Cameron W., Wang, Lu, Squatrito, Massimo, Sasayama, Takashi, Nakada, Mitsutoshi, Huse, Jason T., Pedraza, Alicia, Utsuki, Satoshi, Yasui, Yoshie, Tandon, Adesh, Fomchenko, Elena I., Oka, Hidehiro, Levine, Ross L., Fujii, Kiyotaka, Ladanyi, Marc, Holland, Eric C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2010
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947772/
https://ncbi.nlm.nih.gov/pubmed/20889717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1972310
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