Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor

Glioblastoma multiforme (GBM) is a lethal brain tumor characterized by intense apoptosis resistance and extensive necrosis. Bcl2L12 (for Bcl2-like 12) is a cytoplasmic and nuclear protein that is overexpressed in primary GBM and functions to inhibit post-mitochondrial apoptosis signaling. Here, we s...

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Detalhes bibliográficos
Main Authors: Stegh, Alexander H., Brennan, Cameron, Mahoney, John A., Forloney, Kristin L., Jenq, Harry T., Luciano, Janina P., Protopopov, Alexei, Chin, Lynda, DePinho, Ronald A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2010
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947771/
https://ncbi.nlm.nih.gov/pubmed/20837658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1924710
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