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Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma

Glioblastoma multiforme (GBM) is a highly aggressive brain cancer that is characterized by the paradoxical features of intense apoptosis resistance yet a marked propensity to undergo necrosis. Bcl2L12 (for Bcl2-Like12) is a nuclear and cytoplasmic oncoprotein that is universally overexpressed in pri...

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Detalhes bibliográficos
Main Authors: Stegh, Alexander H., Kesari, Santosh, Mahoney, John E., Jenq, Harry T., Forloney, Kristin L., Protopopov, Alexei, Louis, David N., Chin, Lynda, DePinho, Ronald A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504776/
https://ncbi.nlm.nih.gov/pubmed/18669646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712034105
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